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Since the start of the pandemic, the lives of care home residents and their relatives have been greatly affected by COVID-19. Efforts to reduce spread of the coronavirus into care homes, such as limiting family visits, have had a significant impact on the health and wellbeing of residents. Therefore, we need to find medications to minimise this impact. Government health ministers have asked us to set up this trial to find out how we can protect care home residents from COVID-19. We will try out different medications to see which ones may help, so that residents can stay well and resume a more normal life.